Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics

Activation of ErbB receptors by epidermal growth factor (EGF) or heregulin (HRG) determines distinct cell fate decisions, although signals propagate through shared pathways. Using modeling and experiments, we unravel how EGF and HRG generate distinct, all-or-none responses of the phosphorylated tran...

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Detalhes bibliográficos
Main Authors: Nakakuki, Takashi, Birtwistle, Marc R., Saeki, Yuko, Yumoto, Noriko, Ide, Kaori, Nagashima, Takeshi, Brusch, Lutz, Ogunnaike, Babatunde A., Hatakeyama, Mariko, Kholodenko, Boris N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888034/
https://ncbi.nlm.nih.gov/pubmed/20493519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.03.054
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