Rem, a member of the RGK GTPases, inhibits recombinant Ca(V)1.2 channels using multiple mechanisms that require distinct conformations of the GTPase

Rad/Rem/Gem/Kir (RGK) GTPases potently inhibit Ca(V)1 and Ca(V)2 (Ca(V)1-2) channels, a paradigm of ion channel regulation by monomeric G-proteins with significant physiological ramifications and potential biotechnology applications. The mechanism(s) underlying how RGK proteins inhibit I(Ca) is unkn...

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Detalles Bibliográficos
Main Authors: Yang, Tingting, Xu, Xianghua, Kernan, Timothy, Wu, Vincent, Colecraft, Henry M
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2010
Assuntos:
Molecular and Cellular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887986/
https://ncbi.nlm.nih.gov/pubmed/20308247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187203
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