Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels

Genetically encoded inhibitors for voltage-dependent Ca(2+) (Ca(V)) channels (GECCIs) are useful research tools and potential therapeutics. Rad/Rem/Rem2/Gem (RGK) proteins are Ras-like G proteins that potently inhibit high voltage-activated (HVA) Ca(2+) (Ca(V)1/Ca(V)2 family) channels, but their non...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Puckerin, Akil A., Chang, Donald D., Shuja, Zunaira, Choudhury, Papiya, Scholz, Joachim, Colecraft, Henry M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255209/
https://ncbi.nlm.nih.gov/pubmed/30397133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811024115
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