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Rem, a member of the RGK GTPases, inhibits recombinant Ca(V)1.2 channels using multiple mechanisms that require distinct conformations of the GTPase
Rad/Rem/Gem/Kir (RGK) GTPases potently inhibit Ca(V)1 and Ca(V)2 (Ca(V)1-2) channels, a paradigm of ion channel regulation by monomeric G-proteins with significant physiological ramifications and potential biotechnology applications. The mechanism(s) underlying how RGK proteins inhibit I(Ca) is unkn...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Science Inc
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887986/ https://ncbi.nlm.nih.gov/pubmed/20308247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187203 |
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