Modified dsRNAs that are not processed by Dicer maintain potency and are incorporated into the RISC

Chemical modification of RNA duplexes can provide practical advantages for RNA interference (RNAi) triggering molecules including increased stability, safety and specificity. The impact of nucleotide modifications on Dicer processing, RISC loading and RNAi-mediated mRNA cleavage was investigated wit...

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Hlavní autoři: Salomon, William, Bulock, Karen, Lapierre, Jennifer, Pavco, Pamela, Woolf, Tod, Kamens, Joanne
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887946/
https://ncbi.nlm.nih.gov/pubmed/20167638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq055
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