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Modified dsRNAs that are not processed by Dicer maintain potency and are incorporated into the RISC
Chemical modification of RNA duplexes can provide practical advantages for RNA interference (RNAi) triggering molecules including increased stability, safety and specificity. The impact of nucleotide modifications on Dicer processing, RISC loading and RNAi-mediated mRNA cleavage was investigated wit...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887946/ https://ncbi.nlm.nih.gov/pubmed/20167638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq055 |
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