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Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

Targeting of cancer stem cells is believed to be essential for curative therapy of cancers, but supporting evidence is limited. Few selective target genes in cancer stem cells have been identified. Here we identify the arachidonate 5-lipoxygenase (5-LO) gene (Alox5) as a critical regulator for leuke...

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Detalhes bibliográficos
Main Authors: Chen, Yaoyu, Hu, Yiguo, Zhang, Haojian, Peng, Cong, Li, Shaoguang
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887745/
https://ncbi.nlm.nih.gov/pubmed/19503090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.389
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