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Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

Targeting of cancer stem cells is believed to be essential for curative therapy of cancers, but supporting evidence is limited. Few selective target genes in cancer stem cells have been identified. Here we identify the arachidonate 5-lipoxygenase (5-LO) gene (Alox5) as a critical regulator for leuke...

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Détails bibliographiques
Auteurs principaux: Chen, Yaoyu, Hu, Yiguo, Zhang, Haojian, Peng, Cong, Li, Shaoguang
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887745/
https://ncbi.nlm.nih.gov/pubmed/19503090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.389
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