Inhaled activated protein C protects mice from ventilator-induced lung injury

INTRODUCTION: Activated Protein C (APC), an endogenous anticoagulant, improves tissue microperfusion and endothelial cell survival in systemic inflammatory states such as sepsis, but intravenous administration may cause severe bleeding. We have thus addressed the role of APC delivered locally by inh...

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Hauptverfasser: Maniatis, Nikolaos A, Letsiou, Eleftheria, Orfanos, Stylianos E, Kardara, Matina, Dimopoulou, Ioanna, Nakos, Georgios, Lekka, Marilena E, Roussos, Charalambos, Armaganidis, Apostolos, Kotanidou, Anastasia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887192/
https://ncbi.nlm.nih.gov/pubmed/20403177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8976
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