Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial

INTRODUCTION: Benzodiazepines and α(2 )adrenoceptor agonists exert opposing effects on innate immunity and mortality in animal models of infection. We hypothesized that sedation with dexmedetomidine (an α(2 )adrenoceptor agonist), as compared with lorazepam (a benzodiazepine), would provide greater...

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Autores principales: Pandharipande, Pratik P, Sanders, Robert D, Girard, Timothy D, McGrane, Stuart, Thompson, Jennifer L, Shintani, Ayumi K, Herr, Daniel L, Maze, Mervyn, Ely, E Wesley
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887145/
https://ncbi.nlm.nih.gov/pubmed/20233428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8916
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