Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial

INTRODUCTION: Benzodiazepines and α(2 )adrenoceptor agonists exert opposing effects on innate immunity and mortality in animal models of infection. We hypothesized that sedation with dexmedetomidine (an α(2 )adrenoceptor agonist), as compared with lorazepam (a benzodiazepine), would provide greater...

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Autors principals: Pandharipande, Pratik P, Sanders, Robert D, Girard, Timothy D, McGrane, Stuart, Thompson, Jennifer L, Shintani, Ayumi K, Herr, Daniel L, Maze, Mervyn, Ely, E Wesley
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887145/
https://ncbi.nlm.nih.gov/pubmed/20233428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8916
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