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Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial

INTRODUCTION: Benzodiazepines and α(2 )adrenoceptor agonists exert opposing effects on innate immunity and mortality in animal models of infection. We hypothesized that sedation with dexmedetomidine (an α(2 )adrenoceptor agonist), as compared with lorazepam (a benzodiazepine), would provide greater...

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書誌詳細
主要な著者: Pandharipande, Pratik P, Sanders, Robert D, Girard, Timothy D, McGrane, Stuart, Thompson, Jennifer L, Shintani, Ayumi K, Herr, Daniel L, Maze, Mervyn, Ely, E Wesley
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887145/
https://ncbi.nlm.nih.gov/pubmed/20233428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8916
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