NOD congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene

We have used the public sequencing and annotation of the mouse genome to delimit the previously resolved type 1 diabetes (T1D) Idd18 interval to a region on chromosome 3 that includes the immunologically relevant candidate gene, Vav3. To test the candidacy of Vav3, we developed a novel congenic stra...

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Autori principali: Fraser, Heather I., Dendrou, Calliope A., Healy, Barry, Rainbow, Daniel B., Howlett, Sarah, Smink, Luc J., Gregory, Simon, Steward, Charles A., Todd, John A., Peterson, Laurence B., Wicker, Linda S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886967/
https://ncbi.nlm.nih.gov/pubmed/20363978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903734
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