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Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability

Pathological lung overdistention associated with mechanical ventilation at high tidal volumes (ventilator-induced lung injury; VILI) compromises endothelial cell (EC) barrier leading to development of pulmonary edema and increased morbidity and mortality. We have previously shown involvement of micr...

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Detalhes bibliográficos
Main Authors: Birukova, Anna A., Fu, Panfeng, Xing, Junjie, Yakubov, Bakhtiyor, Cokic, Ivan, Birukov, Konstantin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886610/
https://ncbi.nlm.nih.gov/pubmed/20348280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00263.2009
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