Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the Polycomb group proteins. The antisense non-coding RNA ANRIL of the INK4b/ARF/INK4a locus is also important for expression...

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Hlavní autoři: Yap, Kyoko L., Li, Side, Muñoz-Cabello, Ana M., Raguz, Selina, Zeng, Lei, Mujtaba, Shiraz, Gil, Jesús, Walsh, Martin J., Zhou, Ming-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886305/
https://ncbi.nlm.nih.gov/pubmed/20541999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.03.021
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