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Extreme-Longevity Mutations Orchestrate Silencing of Multiple Signaling Pathways

Long-lived mutants provide unique insights into the genetic factors that limit lifespan in wild-type animals. Most mutants and RNA-interference targets found to extend life, typically by 1.5- to 2.5-fold, were discovered in C. elegans. Several longevity-assurance pathways are conserved across widely...

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Autores principales: Shmookler Reis, Robert J., Bharill, Puneet, Tazearslan, Cagdas, Ayyadevara, Srinivas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885961/
https://ncbi.nlm.nih.gov/pubmed/19465083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2009.05.011
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