Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors

BACKGROUND: The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. To fur...

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Hlavní autoři: Olsson, Anders, Björk, Anders, Vallon-Christersson, Johan, Isaacs, John T, Leanderson, Tomas
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885345/
https://ncbi.nlm.nih.gov/pubmed/20470445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-107
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