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Removal of the Cardiac Troponin I N-terminal Extension Improves Cardiac Function in Aged Mice
The cardiac troponin I (cTnI) isoform contains a unique N-terminal extension that functions to modulate activation of cardiac myofilaments. During cardiac remodeling restricted proteolysis of cTnI removes this cardiac specific N-terminal modulatory extension to alter myofilament regulation. We have...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2885247/ https://ncbi.nlm.nih.gov/pubmed/20410305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.086892 |
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