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Removal of the N-terminal Extension of Cardiac Troponin I as a Functional Compensation for Impaired Myocardial β-Adrenergic Signaling

Although β-adrenergic stimuli are essential for myocardial contractility, β-blockers have a proven beneficial effect on the treatment of heart failure, but the mechanism is not fully understood. The stimulatory G protein α-subunit (G(s)α) couples the β-adrenoreceptor to adenylyl cyclase and the intr...

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Détails bibliographiques
Auteurs principaux: Feng, Han-Zhong, Chen, Min, Weinstein, Lee S., Jin, Jian-Ping
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586242/
https://ncbi.nlm.nih.gov/pubmed/18815135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803302200
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