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Peroxisome Proliferator-activated Receptor γ Coactivator 1α or 1β Overexpression Inhibits Muscle Protein Degradation, Induction of Ubiquitin Ligases, and Disuse Atrophy

Overexpression of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), like exercise, increases mitochondrial content and inhibits muscle atrophy. To understand these actions, we tested whether PGC-1α or its close homolog, PGC-1β, influences muscle pr...

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Detalhes bibliográficos
Main Authors: Brault, Jeffrey J., Jespersen, Jakob G., Goldberg, Alfred L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885225/
https://ncbi.nlm.nih.gov/pubmed/20404331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.113092
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