Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins

Approximately 15 % of human prion disease is associated with autosomal-dominant pathogenic mutations in the prion protein (PrP) gene. Previous attempts to model these diseases in mice have expressed human PrP mutations in murine PrP, but this may have different structural consequences. Here, we desc...

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Detalles Bibliográficos
Autores principales: Asante, Emmanuel A., Gowland, Ian, Grimshaw, Andrew, Linehan, Jacqueline M., Smidak, Michelle, Houghton, Richard, Osiguwa, Olufunmilayo, Tomlinson, Andrew, Joiner, Susan, Brandner, Sebastian, Wadsworth, Jonathan D. F., Collinge, John
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for General Microbiology 2009
Materias:
Jgv Direct
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885063/
https://ncbi.nlm.nih.gov/pubmed/19218199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.007930-0
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