Dissociation of pathological and molecular phenotype of variant Creutzfeldt–Jakob disease in transgenic human prion protein 129 heterozygous mice

All neuropathologically confirmed cases of variant Creutzfeldt–Jakob disease (vCJD), characterized by abundant florid plaques and type 4 disease-related prion protein (PrP(Sc)) in the brain, have been homozygous for methionine at polymorphic residue 129 of PRNP. The distinctive neuropathological and...

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Bibliografski detalji
Glavni autori: Asante, Emmanuel A., Linehan, Jacqueline M., Gowland, Ian, Joiner, Susan, Fox, Katie, Cooper, Sharon, Osiguwa, Olufumilayo, Gorry, Michelle, Welch, Julie, Houghton, Richard, Desbruslais, Melanie, Brandner, Sebastian, Wadsworth, Jonathan D. F., Collinge, John
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502304/
https://ncbi.nlm.nih.gov/pubmed/16809423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604292103
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