BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein

Variant Creutzfeldt–Jakob disease (vCJD) has been recognized to date only in individuals homozygous for methionine at PRNP codon 129. Here we show that transgenic mice expressing human PrP methionine 129, inoculated with either bovine spongiform encephalopathy (BSE) or variant CJD prions, may develo...

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Detalhes bibliográficos
Main Authors: Asante, Emmanuel A., Linehan, Jacqueline M., Desbruslais, Melanie, Joiner, Susan, Gowland, Ian, Wood, Andrew L., Welch, Julie, Hill, Andrew F., Lloyd, Sarah E., Wadsworth, Jonathan D.F., Collinge, John
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136957/
https://ncbi.nlm.nih.gov/pubmed/12456643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf653
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