Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast.

The products of the collagen-alpha 1(I) and -alpha 2(I) genes form the triple helical molecule collagen type I, which constitutes the major ECM protein in tissue fibrosis. The collagen-alpha 1(I) gene is mainly transcriptionally regulated, and its promoter activity depends on the interaction of the...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Nehls, M C, Brenner, D A, Gruss, H J, Dierbach, H, Mertelsmann, R, Herrmann, F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288495/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7504695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116914
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