Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast.
The products of the collagen-alpha 1(I) and -alpha 2(I) genes form the triple helical molecule collagen type I, which constitutes the major ECM protein in tissue fibrosis. The collagen-alpha 1(I) gene is mainly transcriptionally regulated, and its promoter activity depends on the interaction of the...
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| Опубликовано в:: | J Clin Invest |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
1993
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288495/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7504695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116914 |
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