Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast.

The products of the collagen-alpha 1(I) and -alpha 2(I) genes form the triple helical molecule collagen type I, which constitutes the major ECM protein in tissue fibrosis. The collagen-alpha 1(I) gene is mainly transcriptionally regulated, and its promoter activity depends on the interaction of the...

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Bibliographic Details
Main Authors: Nehls, M C, Brenner, D A, Gruss, H J, Dierbach, H, Mertelsmann, R, Herrmann, F
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC288495/
https://ncbi.nlm.nih.gov/pubmed/7504695
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