Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.

Excessive production of collagen type I is a major contributor to hepatic fibrosis. Activated (myofibroblastic), but not quiescent, hepatic stellate cells (lipocytes) have a high level of collagen type I and alpha-smooth muscle actin expression. Therefore, stellate cell activation is a critical step...

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Publié dans:	J Clin Invest
Auteurs principaux:	Lee, K S, Buck, M, Houglum, K, Chojkier, M
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185899/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7593635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118304
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