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High Prevalence of Dihydropteroate Synthase Mutations in Pneumocystis jirovecii Isolated from Patients with Pneumocystis Pneumonia in South Africa

Pneumocystis jirovecii pneumonia (PCP) is an important cause of morbidity and mortality in immunocompromised patients. Sulfa-containing drugs are used for the treatment and prophylaxis of PCP. Mutations in the P. jirovecii fas gene, which encodes dihydropteroate synthase (DHPS), are associated with...

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Main Authors: Dini, Leigh, du Plessis, Mignon, Frean, John, Fernandez, Victor
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884465/
https://ncbi.nlm.nih.gov/pubmed/20351205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02004-09
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