Dihydropteroate Synthase and Novel Dihydrofolate Reductase Gene Mutations in Strains of Pneumocystis jirovecii from South Africa

Dihydropteroate synthase (DHPS) gene mutations have raised concerns about emerging sulfonamide resistance in Pneumocystis jirovecii. DHPS and dihydrofolate reductase (DHFR) gene products were amplified in clinical specimens from South African patients. One of 53 DHPS genes sequenced contained the do...

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Detalhes bibliográficos
Main Authors: Robberts, F. J. L., Chalkley, L. J., Weyer, K., Goussard, P., Liebowitz, L. D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mycology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1081295/
https://ncbi.nlm.nih.gov/pubmed/15750128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.43.3.1443-1444.2005
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