Deficiency of cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) accelerates atherogenesis in apolipoprotein E-deficient mice

Cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), are upregulated during vascular cell proliferation and negatively regulate growth of vascular cells. We hypothesized that absence of either p21(Cip1) or p27(Kip1) in apolipoprotein E (apoE)-deficiency may increase atherosclerotic plaque fo...

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Bibliografiska uppgifter
Huvudupphovsmän: Akyürek, Levent M., Boehm, Manfred, Olive, Michelle, Zhou, Alex-Xianghua, San, Hong, Nabel, Elizabeth G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884298/
https://ncbi.nlm.nih.gov/pubmed/20417618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.04.097
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