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An Electrostatic Model for DNA Surface Hybridization

DNA hybridization at surfaces is a crucial process for biomolecular detection, genotyping, and gene expression analysis. However, hybridization density and kinetics can be strongly inhibited by electric fields from the negatively charged DNA as the reaction proceeds. Here, we develop an electrostati...

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Bibliografiske detaljer
Main Authors: Wong, Ian Y., Melosh, Nicholas A.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884251/
https://ncbi.nlm.nih.gov/pubmed/20550908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.017
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