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Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B cell metastases

PURPOSE: A drug of high potency and reduced immunogenicity is needed to develop a targeted biological drug that when injected systemically can penetrate to malignant B cells. Therefore, a novel deimmunized bispecific ligand directed toxin (BLT) targeted by dual high affinity scFvs spliced to PE38 wi...

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Bibliografiske detaljer
Main Authors: Vallera, Daniel A., Oh, Seunguk, Chen, Hua, Shu, Yanqun, Frankel, Arthur E.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884080/
https://ncbi.nlm.nih.gov/pubmed/20530709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0203
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