Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene

BACKGROUND: Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dependence after long-term use, which has limited their clinical use. We previousl...

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Main Authors: Chen, Shiou-Lan, Ma, Hsin-I, Han, Jun-Ming, Lu, Ru-Band, Tao, Pao-Luh, Law, Ping-Yee, Loh, Horace H
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883971/
https://ncbi.nlm.nih.gov/pubmed/20403204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-28
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