Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene

BACKGROUND: Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dependence after long-term use, which has limited their clinical use. We previousl...

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Hlavní autoři: Chen, Shiou-Lan, Ma, Hsin-I, Han, Jun-Ming, Lu, Ru-Band, Tao, Pao-Luh, Law, Ping-Yee, Loh, Horace H
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883971/
https://ncbi.nlm.nih.gov/pubmed/20403204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-28
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