Low-Penetrance Susceptibility Variants in Familial Colorectal Cancer

BACKROUND: Genome-wide association studies have identified ten low-penetrance loci that confer modestly increased risk of colorectal cancer (CRC). Although they underlie a significant proportion of CRC in the general population, their impact on the familial risk of CRC has yet to be formally enumera...

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Autori principali: Niittymäki, Iina, Kaasinen, Eevi, Tuupanen, Sari, Karhu, Auli, Järvinen, Heikki, Mecklin, Jukka-Pekka, Tomlinson, Ian P.M., Di Bernardo, Maria Chiara, Houlston, Richard S., Aaltonen, Lauri A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883738/
https://ncbi.nlm.nih.gov/pubmed/20501757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-09-1320
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