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Numbers of mutations to different types of colorectal cancer

BACKGROUND: The numbers of oncogenic mutations required for transformation are uncertain but may be inferred from how cancer frequencies increase with aging. Cancers requiring more mutations will tend to appear later in life. This type of approach may be confounded by biologic heterogeneity because...

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Autori principali: Calabrese, Peter, Mecklin, Jukka-Pekka, Järvinen, Heikki J, Aaltonen, Lauri A, Tavaré, Simon, Shibata, Darryl
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1266026/
https://ncbi.nlm.nih.gov/pubmed/16202134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-126
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