Numbers of mutations to different types of colorectal cancer

BACKGROUND: The numbers of oncogenic mutations required for transformation are uncertain but may be inferred from how cancer frequencies increase with aging. Cancers requiring more mutations will tend to appear later in life. This type of approach may be confounded by biologic heterogeneity because...

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Главные авторы: Calabrese, Peter, Mecklin, Jukka-Pekka, Järvinen, Heikki J, Aaltonen, Lauri A, Tavaré, Simon, Shibata, Darryl
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2005
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1266026/
https://ncbi.nlm.nih.gov/pubmed/16202134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-126
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