Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

BACKGROUND: Cancer cells are highly dependent on glycolysis. Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer cells over normal cells, and to examine the underlying mechanisms. METHODS: Represen...

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Bibliographic Details
Main Authors: Madhok, B M, Yeluri, S, Perry, S L, Hughes, T A, Jayne, D G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
Subjects:
Molecular Diagnostics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883702/
https://ncbi.nlm.nih.gov/pubmed/20485289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605701
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