Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells

Colorectal cancer (CRC) is one of the most frequent, malignant gastrointestinal tumors, and strategies and effectiveness of current therapy are limited. A series of benzimidazole-isoquinolinone derivatives (BIDs) was synthesized and screened to identify novel scaffolds for CRC. Of the compounds eval...

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Publicado no:Bioorg Med Chem
Principais autores: He, Liu-Jun, Yang, Dong-Lin, Li, Shi-Qiang, Zhang, Ya-Jun, Tang, Yan, Lei, Jie, Frett, Brendan, Lin, Hui-kuan, Li, Hong-yu, Chen, Zhong-Zhu, Xu, Zhi-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718200/
https://ncbi.nlm.nih.gov/pubmed/29921474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.06.010
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