Metabolism of short-chain ceramide by human cancer cells-implications for therapeutic approaches

Due to recent use of short-chain ceramides in preclinical studies, we characterized C6-ceramide metabolism in cancer cell lines and assessed metabolic junctures for enhancing efficacy. MDA-MB-231 breast cancer cells decreased the amount of C6-ceramide metabolized to C6-sphingomyelin (C6-SM) and incr...

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Main Authors: Chapman, Jacqueline V., Gouazé-Andersson, Valérie, Messner, Maria C., Flowers, Margaret, Karimi, Ramin, Kester, Mark, Barth, Brian M., Liu, Xin, Liu, Yong-Yu, Giuliano, Armando E., Cabot, Myles C.
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883648/
https://ncbi.nlm.nih.gov/pubmed/20385104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.04.001
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