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Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK – dependent processing of DNA termini in NHEJ catalyzed DSB repair

Artemis is a member of the β–CASP family of nucleases in the metallo-β-lactamase superfamily of hydrolases. Artemis has been demonstrated to be involved in V(D)J-recombination and in the NHEJ-catalyzed repair of DNA DSBs. In vitro, both DNA-PK independent 5’ to 3’ exonuclease activity and DNA-PK dep...

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Sonraí Bibleagrafaíochta
Main Authors: Pawelczak, Katherine S., Turchi, John J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883643/
https://ncbi.nlm.nih.gov/pubmed/20347402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.03.002
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