Učitavanje...
Artemis is required to improve the accuracy of repair of double-strand breaks with 5′-blocked termini generated from non-DSB-clustered lesions
Clustered DNA lesions are defined as ≥2 damage events within 20bp. Oxidised bases, abasic (AP) sites, single-strand breaks and double-strand breaks (DSBs) exist in radiation-induced clusters, and these lesions are more difficult to repair and can be more mutagenic than single lesions. Understanding...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630522/ https://ncbi.nlm.nih.gov/pubmed/23448902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/get009 |
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