The Telomerase Antagonist Imetelstat Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth

PURPOSE: Telomerase activity is one of the hallmarks of cancer and is a highly relevant therapeutic target. The effects of a novel human telomerase antagonist, imetelstat, on primary human glioblastoma (GBM) tumor-initiating cells were investigated in vitro and in vivo. EXPERIMENTAL DESIGN: Tumor-in...

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Main Authors: Marian, Calin O., Cho, Steve K., McEllin, Brian M., Maher, Elizabeth A., Hatanpaa, Kimmo J., Madden, Christopher J., Mickey, Bruce E., Wright, Woodring E., Shay, Jerry W., Bachoo, Robert M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883447/
https://ncbi.nlm.nih.gov/pubmed/20048334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2850
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