SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients

Recent studies in mice have demonstrated that the protein tyrosine phosphatase SHP-1 is a crucial negative regulator of cytokine signaling, inflammatory gene expression, and demyelination in central nervous system. The present study investigates a possible similar role for SHP-1 in the human disease...

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Bibliographic Details
Main Authors: Christophi, George P, Hudson, Chad A, Gruber, Ross C, Christophi, Christoforos P, Mihai, Cornelia, Mejico, Luis J, Jubelt, Burk, Massa, Paul T
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883308/
https://ncbi.nlm.nih.gov/pubmed/18209728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.3700720
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