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Regulated Degradation of Spindle Assembly Factors by the Anaphase-Promoting Complex
The ubiquitin ligase anaphase-promoting complex (APC/C) is essential for cell division in all eukaryotes. Loss of APC/C-activity arrests cells at metaphase and results in severe aberrations of the mitotic spindle, but how the APC/C regulates spindle formation is not understood. Here, we report that...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883244/ https://ncbi.nlm.nih.gov/pubmed/20471943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.02.038 |
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