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Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases

Lipoxygenases catalyse the oxidation of polyunsaturated fatty acids and have been invoked in many diseases including cancer, atherosclerosis and Alzheimer’s disease. Currently, no X-ray structures are available with substrate or substrate analogues bound in a productive conformation. Such structures...

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Autori principali: Jacquot, Cyril, McGinley, Chris M., Plata, Erik, Holman, Theodore R., van der Donk, Wilfred A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883171/
https://ncbi.nlm.nih.gov/pubmed/18972057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b808003h
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