TRANSIENT INDUCTION OF ANG II-DEPENDENT MALIGNANT HYPERTENSION CAUSES SUSTAINED ELEVATION OF BLOOD PRESSURE AND AUGMENTATION OF THE PRESSOR RESPONSE TO ANG II IN CYP1A1-REN2 TRANSGENIC RATS

BACKGROUND: Transgenic rats with inducible expression of the mouse Ren2 renin gene [strain name: TGR(Cyp1a1Ren2)] allow induction of various degrees of ANG II-dependent hypertension. Dietary administration of the aryl hydrocarbon indole-3-carbinol (I3C) at a dose of 0.15% induces a slowly developing...

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Bibliographic Details
Main Authors: Howard, Catherine G., Mullins, John J., Mitchell, Kenneth D.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882982/
https://ncbi.nlm.nih.gov/pubmed/20375689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MAJ.0b013e3181d82a62
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