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Synthesis and Evaluation of Estradiol Derivatives as Anti-Breast Cancer Agents
3-N-alkyloxyestradiol derivatives were synthesized, characterized and tested for activity in MCF-7 human breast cancer cells. Among the compounds, the diisopropyl and piperidinyl derivatives were found to be more active than 4-hydroxytamoxifen (HO-Tam), the active metabolite of tamoxifen based upon...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882686/ https://ncbi.nlm.nih.gov/pubmed/20543998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/157018010791306551 |
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