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Synthesis and Evaluation of Estradiol Derivatives as Anti-Breast Cancer Agents

3-N-alkyloxyestradiol derivatives were synthesized, characterized and tested for activity in MCF-7 human breast cancer cells. Among the compounds, the diisopropyl and piperidinyl derivatives were found to be more active than 4-hydroxytamoxifen (HO-Tam), the active metabolite of tamoxifen based upon...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Cooperwood, John S., Edwards, Jesse, Musa, Musiliyu, Simmons, Devora, Mian, Abdul D., Park, Kwon-kyun, Wan, Zhongliang
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882686/
https://ncbi.nlm.nih.gov/pubmed/20543998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/157018010791306551
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