Prolonged survival and improved glycemia in BB diabetic rats after early sustained exposure to GLP-1

BACKGROUND: Type I diabetes (T1D) in both humans and BioBreeding (BB) rats is an autoimmune disease that results in complete destruction of islets and insulin dependency for life. Glucagon-like peptide 1 (GLP-1) promotes β cell proliferation and neogenesis and has a potent insulinotropic effect. We...

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Autori principali: Yanay, Ofer, Moralejo, Daniel, Kernan, Kelly, Brzezinski, Margaret, Fuller, Jessica M., Barton, Randall, Lernmark, Ake, Osborne, William R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882674/
https://ncbi.nlm.nih.gov/pubmed/20527046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1466
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