A Synthetic Analogue of 20-HETE, 5,14-HEDGE, Reverses Endotoxin-Induced Hypotension via Increased 20-HETE Levels Associated with Decreased iNOS Protein Expression and Vasodilator Prostanoid Production in Rats

Nitric oxide (NO) produced by inducible NO synthase (iNOS) is responsible for endotoxin-induced hypotension and vascular hyporeactivity and plays a major contributory role in the multiorgan failure. Endotoxic shock is also associated with an increase in vasodilator prostanoids as well as a decrease...

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Detalhes bibliográficos
Main Authors: Cuez, Tuba, Korkmaz, Belma, Buharalioglu, C. Kemal, Sahan-Firat, Seyhan, Falck, John, Malik, Kafait U., Tunctan, Bahar
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882512/
https://ncbi.nlm.nih.gov/pubmed/20002062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-7843.2009.00501.x
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