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A Synthetic Analogue of 20-HETE, 5,14-HEDGE, Reverses Endotoxin-Induced Hypotension via Increased 20-HETE Levels Associated with Decreased iNOS Protein Expression and Vasodilator Prostanoid Production in Rats
Nitric oxide (NO) produced by inducible NO synthase (iNOS) is responsible for endotoxin-induced hypotension and vascular hyporeactivity and plays a major contributory role in the multiorgan failure. Endotoxic shock is also associated with an increase in vasodilator prostanoids as well as a decrease...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882512/ https://ncbi.nlm.nih.gov/pubmed/20002062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-7843.2009.00501.x |
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