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Alpha-lipoic acid increases energy expenditure by enhancing AMPK-PGC-1α signalling in the skeletal muscle of aged mice

OBJECTIVES: Skeletal muscle mitochondrial dysfunction is associated with aging and diabetes, which decreases respiratory capacity and increases reactive oxygen species. Lipoic acid (LA) possesses antioxidative and antidiabetic properties. Metabolic action of LA ismediated by activation of AMP-activa...

詳細記述

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書誌詳細
主要な著者: Wang, Yi, Li, Xiaojie, Guo, Yuming, Chan, Lawrence, Guan, Xinfu
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882509/
https://ncbi.nlm.nih.gov/pubmed/20015518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2009.10.018
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