Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation

BACKGROUND: The low density lipoprotein receptor-related protein-6 (LRP6) is an essential co-receptor for canonical Wnt signaling. Dickkopf 1 (Dkk1), a major secreted Wnt signaling antagonist, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts....

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Main Authors: Li, Yonghe, Lu, Wenyan, King, Taj D., Liu, Chia-Chen, Bijur, Gautam N., Bu, Guojun
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2010
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882367/
https://ncbi.nlm.nih.gov/pubmed/20543981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011014
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